Zhilei Chen

Assistant Professor

Research Page

Telephone: (979) 862-1610
Fax Number: (979) 845-6446
E-mail: zhilei.chen@chemail.tamu.edu

Mailing Address...
Jack E. Brown Engineering Building
3122 TAMU
College Station, TX 77843-3122

Education

Ph.D., University of Illinois, Urbana-Champaign, 2006
B.S., East China Normal University, Shanghai, 2000

Awards & Honors

Eugene Rabinowitch Fellowship, University of Illinois, Urbana-Champaign, 2006

Research Interests

Dr. Chen’s research involves applying protein engineering principles for biomedical applications. One of her interests is to engineer novel agents for the treatment of various viral infections, including hepatitis C virus and HIV. She also is working toward developing new technologies to facilitate applications such as gene therapy, tissue engineering, drug delivery and identification of novel drug targets.

Selected Publications

Chen, Z., Wen, F., Sun, N. and Zhao, H. “Directed Evolution of Homing Endonuclease I-SceI with Altered Sequence Specificity.” Protein Engineering, Design & Selection.22, 249-256 (2009).

Chen, Z. and Zhao, H. “Protein Design.” In Encyclopedia of Chemical Processing, (S. Lee, Ed.) pp. 2467-2477, Marcel Dekker, Inc., New York, NY (2006).

Chen, Z. and Zhao, H. “A Highly Sensitive Selection Method for Directed Evolution of Homing Endonucleases.” Nucleic Acids Research, 33, e154 (2005).

Chockalingam, K., Chen, Z., Katzenellenbogen, J. A., and Zhao, H. “Directed Evolution of New Specific Receptor-Ligand Pairs for Use in the Creation of Gene Switches.” Proceedings of the National Academy of Sciences of the United States of America, 102, 5691-5696 (2005).

Chen, Z., Katzenellenbogen, B. S., Katzenellenbogen, J. A. and Zhao, H. “Directed Evolution of Human Estrogen Receptor Variants with Significantly Enhanced Androgen Specificity and Affinity.” Journal of Biological Chemistry, 279, 33855-33864 (2004).


For a complete list of publications, please click here